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**Penyebab sepsis** bisa sangat beragam. Infeksi yang paling umum menyebabkan sepsis termasuk pneumonia (infeksi paru-paru), infeksi saluran kemih, infeksi kulit, dan infeksi setelah operasi. Siapa pun bisa terkena sepsis, tetapi ada beberapa kelompok yang berisiko lebih tinggi, termasuk bayi, orang tua, orang dengan sistem kekebalan tubuh yang lemah (misalnya, penderita HIV/AIDS atau orang yang menjalani kemoterapi), dan orang dengan luka atau cedera serius.
